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Drugging the Undruggable | The Scientist Journal®

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This webinar can be hosted stay and obtainable on-demand

Monday, December sixteenth, 2024
12:30 – 2:00 PM ET 

Focused therapies are remodeling the medical discipline by enabling clinicians to exactly and successfully deal with sufferers with severe ailments. Nonetheless, many proteins, akin to these categorized as transcription elements, small GTPases, and phosphatases, have problem interacting with drug compounds. Consequently, scientists contemplate these targets undruggable.

On this webinar delivered to you by The Scientist, Andrew Tsourkas and Chris Parker will focus on how they’re turning the phrase “undruggable” on its head by using new approaches to focus on undruggable proteins concerned in most cancers, autoimmune ailments, and past. 

Subjects to be coated

  • Engineering a system to ship antibodies and different protein-based focusing on ligands into the cytosol to inhibit and degrade cancer-associated proteins
  • Growing photoaffinity-based chemical proteomic methods to establish small molecule binding websites on proteins and utilizing this info to design chemical probes towards disease-relevant targets
Andrew

Andrew Tsourkas, PhD
Professor, Division of Bioengineering
Co-director, Middle for Focused Therapeutics and Translational Nanomedicine
College of Pennsylvania

Chris

Chris Parker, PhD
Professor
Division of Chemistry
The Scripps Analysis Institute

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